• In conclusion we have found that Egr can play an

  2021-02-10

  

  In conclusion, we have found that Egr1 can play an inhibitory role on DBH promoter-driven transcription. This inhibition requires a newly identified Egr1 response bicuculline synthesis at the −227/−224 region of DBH promoter. This inhibition appears to result from Egr1 directly bound to the DBH pro

• The present study was set to characterise

  2021-02-10

  

  The present study was set to characterise the DNMT gene orthologs and describe the expression patterns of these genes during seed development in natural diploid apomict B. divaricarpa and diploid sexual B. stricta. Material and methods Results The B. stricta genome v1.2, was sequenced and ass

• Family and twin studies have estimated

  2021-02-10

  

  Family and twin studies have estimated the heritability of obesity to be between 40 and 70% [5], [6], [7]. However, all known risk variants can only account for ∼3% of the variance in BMI [8], [9]. Therefore, alternate methods are needed to identify additional risk factors. In recent decades, Drosop

• The first purpose of the current study was to

  2021-02-10

  

  The first purpose of the current study was to characterize a standardized experimental model of postprandial hyperlipidemia in various rodent species. To our knowledge this study provides the most comprehensive and systematic evaluation of rodent models of postprandial hyperlipidemia to date. We ada

• Our observation that FAK is downregulated

  2021-02-10

  

  Our observation that FAK is downregulated in vascular smooth muscle Pepstatin A on fibrillar collagen confirms observations reported for other cell types [14]. However, unlike the results reported previously [14], our work suggests that matrix rigidity per se does not determine FAK downregulation.

• br Contributors br Acknowledgements br Introduction Pemphigu

  2021-02-10

  

  Contributors Acknowledgements Introduction Pemphigus disorders are characterized by autoantibodies binding to desmosomes between epidermal cells, resulting in the loss of cell to cell adhesion and blister formation. In pemphigus foliaceus, autoantibodies predominantly bind to desmoglein 1,

• Cucurbitacin I Investigations of mice lacking up

  2021-02-10

  

  Investigations of mice lacking up to three CDKs identified the mitosis-regulating kinase CDK1 as the main essential component for the cell cycle, whereas ablation of other Cucurbitacin I regulators such as CDK2, CDK4, or CDK6 did not result in defective proliferation 12, 13. Mouse models and specifi

• What is the predominant mechanism underlying the benefits

  2021-02-09

  

  What is the predominant mechanism underlying the benefits of udenafil, i.e. the vascular vs. myocardial effect? Lewis et al. suggested that the benefit of sildenafil in HFrEF would be derived from augmented RV systolic function that mainly results from pulmonary vasodilation, suggestive of the ‘vasc

• br Concluding remarks br Transparency document br

  2021-02-09

  

  Concluding remarks Transparency document Acknowledgements Research reported in this publication was supported by the National Cancer Institute of the National Institutes of Health under award number P30CA033572 (RS). The content is solely the responsibility of the authors and does not nece

• br Materials and methods br

  2021-02-09

  

  Materials and methods Results Discussion The nitric oxide generating enzymes of the NOS family comprise three isoforms: nNOS, iNOS and eNOS [31]. Expression of eNOS is mainly found in endothelial ag1478 where it physically promotes vasodilation [32]. Conversely, evidence also indicates tha

• The effects of the endocrine active agents on hepatic ER

  2021-02-09

  

  The effects of the endocrine active agents on hepatic ERα were varied. Both nonylphenol and genistein caused an increase in hepatic ERα in female rats, whereas EE2 did not. It is doubtful that the small changes in hepatic ERα induced by genistein and nonylphenol in female rats are sufficient to alte

• OHC is a potent regulator of

  2021-02-09

  

  25-OHC is a potent regulator of LXR-mediated pathways, that impact on Imeglimin lipid homeostasis [8]. This oxysterol affects expression of the cholesterol efflux pumps ATP-binding cassette transporter (ABC)A1 [9] and ABCG1, and expression of apolipoprotein E [10], [11], [12]. 25-OHC is able to sti

• Ubiquitination can occur on a single monoubiquitination or

  2021-02-09

  

  Ubiquitination can occur on a single (monoubiquitination) or several (multiubiquitination) lysine residues, or the same lysine residue can be subjected to several rounds of Ub conjugation (polyubiquitination). Ub bonds within polyUb chains are formed through 1 of 7 lysine residues in Ub, and the typ

• There are numerous theories of schizophrenia etiopathology

  2021-02-09

  

  There are numerous theories of schizophrenia etiopathology and genetics is often taken into consideration [25]. The dopamine D2 receptor is important since it is blocked by typical antipsychotic drugs with high affinity which is correlated with the ability to control psychotic symptoms in schizophre

• The kinase activity of DNA PKcs is essential for NHEJ

  2021-02-09

  

  The kinase activity of DNA-PKcs is essential for NHEJ, but the exact role of the enzymatic activity of DNA-PKcs plays in NHEJ is not fully understood [57]. In vitro, DNA-PKcs can phosphorylate each of the canonical NHEJ factors including Ku70/80 [58], [59], XRCC4 [60], [61], cAMPS-Rp, triethylammoni

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