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Although NO may act as
2021-11-01

Although, NO2− may act as the substrate for NO biosynthesis no strict correlation between NO2− fluctuation in roots and NO content was observed in tomato roots. As the culture period was prolonged NO2− concentration declined in control and m-Tyr exposed seedlings, and finally its concentration was s
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br Funding This work was partially supported by
2021-11-01

Funding This work was partially supported by the National Institute on Alcohol Abuse and Alcoholism, award R00AA021264, startup funds from the Department of Immunology, Herbert Wertheim College of Medicine, and the Office of Research and Economic Development at FIU, and pilot funds from Dr. Werth
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Our data for glucose and
2021-11-01

Our data for glucose and insulin tolerance tests indicate that niacin-induced hyperglycemia is proportional to the degree of insulin resistance induced, implying that there is deterioration in islet function with niacin treatment (McCulloch et al., 1991). In this regard, we have demonstrated, for th
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Wasting syndrome is a common complication of HIV
2021-11-01

Wasting syndrome is a common complication of HIV infection and is marked by progressive weight loss and weakness, often associated with fever (Weinroth et al., 1995). Fever is a highly complex process initiated by the action on the Calpain Inhibitor II, ALLM thermosensitive cells of a number of endo
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Pediatric cancers are fundamentally different from adult
2021-11-01

Pediatric cancers are fundamentally different from adult tumors and usually display a lower mutational burden and a faster growth rate. About 30% of all childhood malignancies are solid tumors and, in a majority of cases, respond well to chemotherapy. However, in particular in neuroblastoma the succ
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In this study we examined whether zebrafish ionocytes might
2021-11-01

In this study, we examined whether zebrafish ionocytes might also share other types of similarity in transport function with kidney cells. In addition to ion transport, mammalian kidney amyloid definition mg also play key roles in xenobiotic elimination, through the action of ATP-Binding Cassette (A
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Amodiaquine dihydrochloride dihydrate We report here a patie
2021-11-01

We report here a patient with a one-base frame-shift deletion in the PURA gene that presented an unusual phenotype including persistent hypoglycorrhachia. We propose a possible link between hypoglycorrhachia and PURA dysfunction postulating PURA as a GLUT1 regulator. We therefore hypothesize that mu
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Regarding the causative diseases of ES patients
2021-11-01

Regarding the causative diseases of ES, patients with unknown cause and those with encephalitis had significantly higher CSF levels of Emodepside sale against GluN2B-NT2 and GluN2B-CT than the disease controls, but patients with genetic disorder and those with cortical dysplasia showed no significa
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It is notable that pharmacological or genetic inhibition
2021-11-01

It is notable that pharmacological or genetic inhibition of GCGR signaling results in the engagement of a number of compensatory mechanisms that potentially impact glucose control. These include alpha-cell hyperplasia [2], [11], [12], [13] and increased beta-cell proliferation under low insulin cond
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br Acknowledgements br Introduction Glucagon a amino acid pe
2021-11-01

Acknowledgements Introduction Glucagon, a 29-amino cpi-613 peptide, is released from the pancreatic islets, intestine and stomach. Glucagon is released under hypoglycemic conditions and then elevates blood glucose levels, serving as a major counter hormone [1]. The regulation of glucose metabo
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SNL in rats led to upregulated Panx
2021-11-01

SNL in rats led to upregulated Panx1 mRNA and protein level in DRG but not in spinal cord, and immunostaining revealed increased Panx1 in DRG neurons [50]. Although it was not emphasized, Panx1 labeling in SGCs was also increased in this pain model. Intrathecal injection of Panx1 blockers or Panx1-s
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Bile acids BAs are detergent like amphipathic
2021-11-01

Bile acids (BAs) are detergent-like amphipathic molecules synthesized from cholesterol in the liver, stored in the gallbladder, and released into the intestine after food intake in order to facilitate the orexin antagonist of dietary lipids and liposoluble vitamins. BAs travel along the intestine an
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To further investigate if GPR was the
2021-11-01

To further investigate if GPR40 was the functional target of these phenylpropiolic glycerol phosphate analogs, GW-1100, a selective antagonist of GPR40-mediated Ca2+ elevations in HEK293 cells with an IC50 value equal to 1 μM, was used to inhibit agonist-induced intracellular calcium flux [15]. HEK2
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br Materials and methods br Results br Discussion It was
2021-11-01

Materials and methods Results Discussion It was previously shown that heterologous DNA vaccines composed of fused cDNA fragments encoding chimeric NH2-terminal human HER2 and COOH-terminal rat neu sequences stimulated stronger antibody responses and protective antitumor immunity than either
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The Hedgehog signaling pathway HH pathway hereafter is
2021-11-01

The Hedgehog signaling pathway (HH pathway hereafter) is vital for development and tissue homeostasis. [4] In recent years, studying the role of the HH pathway in carcinogenesis and cancer stemness has highlighted the HH inhibitors as putative cancer therapeutics [5]. However, clinical application o
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