• 5-Methyl-CTP: Catalyzing a Paradigm Shift in mRNA Synthes...

  2025-10-23

  This thought-leadership article unpacks the mechanistic and translational value of 5-Methyl-CTP—a 5-methyl modified cytidine triphosphate—within the evolving mRNA landscape. Bridging biological rationale, experimental breakthroughs (including OMV-based delivery), and strategic guidance, it illuminates why enhanced mRNA stability and translation efficiency are now foundational to next-generation gene expression research and mRNA drug development. Designed for forward-thinking translational researchers, this analysis transcends standard product pages by integrating cutting-edge evidence, clinical relevance, and actionable recommendations.

• Irinotecan in Colorectal Cancer Research: Applied Workflo...

  2025-10-22

  Irinotecan (CPT-11) unlocks new frontiers in colorectal cancer research by enabling precise modeling of DNA damage and apoptosis in physiologically relevant tumor systems. Harness its topoisomerase I inhibition and robust performance in assembloid workflows to accelerate biomarker discovery, therapeutic optimization, and translational insights.

• Imatinib (STI571): Precision Tyrosine Kinase Inhibitor in...

  2025-10-21

  Imatinib (STI571) is transforming signal transduction and cancer biology research through its selective inhibition of PDGF receptor, c-Kit, and Abl kinases. With unrivaled specificity and proven performance in both in vitro and complex assembloid models, Imatinib empowers researchers to dissect tumor microenvironment dynamics and resistance mechanisms with clarity and precision.

• A large number of aldose reductase inhibitors have been

  2025-03-03

  

  A large number of aldose reductase inhibitors have been prepared synthetically, and a limited number of them are therapeutically used. However, none of them is satisfactory. Here, Cannabis extracts with high content of non-psychotropic phytocannabinoids CBD/CBDA or CBG/CBGA showed statistically sign

• We found that several anticancer drugs inhibit HT receptor

  2025-03-03

  

  We found that several anticancer drugs inhibit 5-HT3 piercetm bca protein assay kit current in vitro. Several studies have suggested that 5-HT3 receptor antagonists have anti-mitogenic and apoptotic effects on colorectal and breast cancer cell lines (Ataee et al., 2010, Hejazi et al., 2015). Irinot

• br Methods br Transparency document

  2025-03-03

  

  Methods Transparency document Introduction Epinephrine (EP) is a critical hormone and catecholamine neurotransmitter in nervous system of mammals.1, 2, 3 It has been known to accelerate and regulate heartbeat, blood pressure, bronchodilation, mydriasis, blood sugar and lipolysis, and can he

• br Materials and methods br

  2025-03-03

  

  Materials and methods Results Discussion The brain is endowed with the 5-LOX enzymatic system (Lammers et al., 1996, Lindgren et al., 1984), but its physiological and pathological roles are still not clear. Inflammation is a characteristic of many neurodegenerative diseases such as Alzheime

• The role of DHT in early teleost embryogenesis is

  2025-03-03

  

  The role of DHT in early teleost embryogenesis is not entirely clear or established, however additional studies that treat fish embryos to DHT or to specific srd5a inhibitors at critical stages of development (i.e. prior to sex differentiation) will shed light on the early functions of this androgen

• Having established the structural requirements for potency i

  2025-03-03

  

  Having established the structural requirements for potency in both the biochemical and biomarker (CRA) assays, we evaluated key compounds in the metabolic stability assay. Disappointingly, we found that all compounds had high intrinsic clearances in mouse microsomes. To ascertain whether the in vitr

• The therapeutic potential of ML induced MET against cells of

  2025-03-01

  

  The therapeutic potential of ML327-induced MET against RGFP966 of mesenchymal origin has not been explored. In the present study, we hypothesized that induction of MET using ML327 would block the growth of ES cells and sensitize to TRAIL-mediated apoptosis. Herein, we report that ML327 induces apopt

• In addition to peroxyl radicals the

  2025-03-01

  

  In addition to peroxyl radicals, the most found radical forms in biological systems, some of assays took into account other free radicals such as superoxide anion, hydroxyl, hydrogen peroxide, singlet oxygen and peroxynitrite. ORAC procedure was also modified using different radical sources such as

• We made a number of choices in the original design

  2025-03-01

  

  We made a number of choices in the original design of our experiments. First, we used only portions of the 5′ and 3′ regulatory elements from S. cerevisiae. The sequences of these regions were known [32] and our goal was to express the Pf-DHFR at low levels. In fact, our choice of only 600 bp of the

• br Results A total of respondents

  2025-03-01

  

  Results A total of 126 respondents completed the survey (68.5% response rate), with at least 65% response rate from each of the four represented sectors (denominators represent the total constituent body of the organization or the total attendees of the meeting): PUC 24 out of 37 (65%), SPUNZA 33

• Introduction Rapeseed oil production is very

  2025-03-01

  

  Introduction Rapeseed oil production is very important not only because of its application in food industry, but also in petrochemical branch. Additionally, post-extraction meal and bagasse from oilseed rape are important sources of proteins in animal feedstuffs production. Oilseed rape (Brassica n

• br Introduction Alzheimer s disease

  2025-03-01

  

  Introduction Alzheimer's disease (AD) is a neurodegenerative disorder and the leading cause of dementia. It is characterized by progressive and irreversible damage to different PF-04449913 areas, resulting in cognitive impairment and behavioral changes (O'Neill, 2013, De Strooper and Karran, 201

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