• Studies have demonstrated that AT plays

  2023-10-09

  

  Studies have demonstrated that AT2 plays a greater role in modulating arterial pressure in females than in males. Chronic low-dose infusion of Ang II decreased blood pressure in female rats at a dose that had negligible effects in males. Furthermore, AT2 blockade eliminates the depressor response to

• br Acknowledgments and Disclosures br Introduction Over the

  2023-10-09

  

  Acknowledgments and Disclosures Introduction Over the last decade, the most visible strategy for the treatment of Alzheimer's disease (AD) has been amyloid β peptide (Aβ) immunotherapy (reviewed in [1]). Although the first efforts with Aβ immunotherapy failed to complete clinical trials [1], A

• br Introduction Metabolic cues are crucial inputs in dictati

  2023-10-09

  

  Introduction Metabolic cues are crucial inputs in dictating acute responses through governing cellular signaling pathways as well as in shaping up long-term transcriptional and epigenetic profiles to control chronic cellular responses (Lu and Thompson, 2012). It has been well documented that meta

• Regenerative mechanisms often require reemployment

  2023-10-08

  

  Regenerative mechanisms often require reemployment of pathways used during development in the embryonic and postnatal periods (Waschek, 2002). PACAP has diverse neurodevelopmental and growth factor-like effects (Botia et al., 2007; Vaudry et al., 2009; Waschek, 2002; Watanabe et al., 2016) and it is

• Since the cloning of ARs in the beginning of the

  2023-10-08

  

  Since the cloning of ARs in the beginning of the 1990s, the efforts to characterize them have led to the accumulation of a substantial amount of experimental data. Decades of site-directed mutagenesis (SDM; Box 1) studies, in combination with pharmacological data and computational modeling, have pa

• The first suggestions that the cleaved intracellular

  2023-10-08

  

  The first suggestions that the cleaved intracellular domain of APP, AICD, might transit to the nucleus and hence selectively regulate gene transcription arose from analogies with the Notch receptor signalling system where similar intra-membrane proteolysis occurs [84], [85] and it was later confirme

• Application of the broad acting HTR antagonist methiothepin

  2023-10-08

  

  Application of the broad-acting 5-HTR antagonist methiothepin (Bard et al., 1996, Hoyer et al., 1994, Peroutka, 1990) converted the TBS-induced response of both thalamocortical and intracortical A1 synapses from LTP to LTD, an effect that was mimicked by the selective 5-HT2R antagonist ketanserin (L

• Autophagy is finalized through the coordinated positioning

  2023-10-08

  

  Autophagy is finalized through the coordinated positioning and fusion of autophagosomes with lysosomes, during which an array of common and specific membrane traffic-associated proteins is mobilized. Among these proteins, small GTPases, like Rab7, Rab34, or Arl8, and their N6022 proteins, regulate

• cox 2 inhibitor br Conflicts of interest br Contributors br

  2023-10-08

  

  Conflicts of interest Contributors Introduction Lipid oxidation and enzymatic activities are some of the most significant problems in the food industry. These reactions lead to changes in chemical composition which in turn reduce the quality and shelf life of food products. Most of the anti

• Since primitive societies plants herbs and seeds rich in phy

  2023-10-08

  

  Since primitive societies, plants, herbs and seeds, rich in phytochemicals, were used due to their benefits in human health. These molecules were shown to present a diverse array of action mechanisms, including antioxidant activity, enzyme stimulation, hormones mimicking and by interfering with DNA

• br Methodology br Antibiotics in

  2023-10-08

  

  Methodology Antibiotics in lakes Antibiotic resistance genes in lakes Perspectives of study on Sodium Phenylbutyrate and ARGs in lakes Conclusion This paper systematically reviewed the distribution of antibiotics and ARGs in global lakes. A total of 57 antibiotics reported at least o

• Analysis of the crystal structures

  2023-10-08

  

  Analysis of the crystal structures of LAPs from E. coli[29], bovine eye lens [30], Pseudomonas putida[27], tomato [31] and P. falciparum[32] revealed that the monomer of M17-family LAP is composed of two domains: the smaller, variable N-terminal domain and the larger, conserved C-terminal domain tha

• It is also possible that adrenoceptor

  2023-10-07

  

  It is also possible that α2-adrenoceptor activation may inhibit glutamate accumulation by upregulating the glutamate-buffering activity of Müller Xylometazoline HCl mg through EAAT1 or adjusting EAAT2 in bipolar cells, as well as the NMDA receptor. Therefore, we investigated whether topical administ

• To our knowledge BAY has not progressed

  2023-10-07

  

  To our knowledge, BAY 60-6583 has not progressed to clinical development and remains to be the only ADORA2B agonist that has been developed.33, 34 Further development of similar compounds would be beneficial in future fibrosis research. One of the limitations of our study is being limited to in vit

• The present in vitro pharmacological experiments revealed th

  2023-10-07

  

  The present in vitro pharmacological experiments revealed that the cholinergic up-regulation of VEGF expression in neurons and astrocytes was mainly mediated by nicotinic AChR and muscarinic AChR, respectively. In addition, neuronal VEGF expression was elevated by endogenous ACh in a manner that was

16122 records 269/1075 page Previous Next First page 上5页 266267268269270 下5页 Last page